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制药压片粉末流动性的评价方法

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制药压片粉末流动性的评价方法

发布日期:2019-12-09 09:13 来源:http://228ascd.com 点击:

粉末压片是常规的固体制剂制药技术。粉末性质如流动性、充填性和可压性等不但影响压片过程的混合和传递等环节,还影响制剂的装量差异、含量均匀度等质量指标。在一些药物粉末自身的流动性和可压性欠佳时,除了改进设备外,还要选择流动性、填充性或可压性良好的辅料来改善粉末性质[1]。本文通过粉体休止角、压缩度、Hausner比值、压缩度、川北方程参数等参数评价粉体的流动性和充填性。


1.休止角法与流动性的关系

AG奔驰宝马多人版ZAIJINGPINGHENGZHUANGTAIXIA,FENTIDUIJIXIEMIANYUDIBUSHUIPINGMIANSUOJIARUIJIAOJIAOZUOXIUZHIJIAO。TASHITONGGUOTEDINGFANGSHISHIFENTIZIRANXIALUODAOTEDINGPINGTAISHANGXINGCHENGDE。XIUZHIJIAOFANYINGFENTIKELIJIANDONGTAIMOCAXISHUDAXIAO。XIUZHIJIAOYUEDA,MOCAXISHUYUEDA,FENTIDELIUDONGXINGYUECHA。YIBANRENWEIXIUZHIJIAOXIAOYU40°SHIFENTIDELIUDONGXINGLIANGHAO,KEMANZUYAPIANGUOCHENGZHONGDUILIUDONGXINGDEYAOQIU。XIUZHIJIAODAYU40°,ZEYAOTONGGUOXIUSHIKELIBIAOMIANHUOTIANJIAFULIAODENGFANGSHILAIGAISHAN。


2.压缩度与流动性的关系

YASUODUSHIZHIFENTIDEZHENSHIMIDUYUSONGZHUANGMIDUZHICHAYUZHENSHIMIDUZHIBI。YASUODUJUYOUJISUANJIANDAN,NENGKUAISUBIJIAOYAOWUYOUXIAOCHENGFEN、FULIAO、CHUFANGLIUDONGXINGCHAYIDETEDIAN。YASUODUYUEXIAO,FENTIDELIUDONGXINGYUEHAO。DANGYASUODUWEI5%~10%SHI,FENMOLIUDONGXINGHAO,11%~15%SHIFENMOLIUDONGXINGLIANGHAO,16%~20%SHIFENMOLIUDONGXINGYIBAN,21%~35%SHIFENMOLIUDONGXINGJIAOCHA[2]。      


3.Hausner(豪斯纳)比与流动性的关系

Hausner(HAOSINA)BISHIZHIFENTIDEZHENSHIMIDUYUSONGZHUANGMIDUZHIBI。HausnerBIZHIDAYU1.5SHIFENTIWEINIANXINGFENTI,LIUDONGXINGHETIANCHONGXINGJIAOCHA;XIAOYU1.2SHIZEBIAOSHIFENTILIUDONGXINGHETIANCHONGXINGLIANGHAO。YIBANRENYASUODUHEHAOSINABIYUFENTILIUDONGXINGZHIJIANDEGUANXIRUXIABIAO[3]:


4.川北方程解析粉体的流动性与充填性

AG奔驰宝马多人版CHUANBEIFANGCHENGSHIMIAOSHUYALIHESHOUYACAILIAOTIJIZHIJIANDEBIANHUAGUANXI,YOURIBENRENCHUANBEIGONGFUYU1956NIANYIJINGYANGONGSHIDEXINGSHITICHU,HOUYOUJINGLILUNTUIDAO,YU1963NIANTICHUYIXIALILUNFANGCHENG:

C=abp/(1+bp)         (1)

SHIZHONGpWEIDANWEIYAZHIYALI;aWEISONGZHUANGKONGXIDU;cWEITIJIYASUOBI;bWEIYASUOXISHU。

BENWENBAYALIGAICHENGZHENDONGCISHU,ZEFANGCHENGZHONGDECHANGSHUKEFANYINGFENMODELIUDONGXINGYUCHONGTIANXING,FANGCHENGKEBIANXINGWEISHI(2):

n/C=n/a+1/ab           (2)

SHIZHONG,nWEIQINGQIAOCISHU;CWEIFENTIDEXIANGDUITIJIJIANXIAOBAIFENSHU;a、bWEICHANGSHU。RUQINGQIAOCISHUnWUXIANDA,ZEa、bKEYONGSHI(3)HESHI(4)BIAOSHI。 


a=C∞=(V0-V∞)/ V0        (3)


1/b=n(Vn-V∞)/ (V0-Vn)    (4)


AG奔驰宝马多人版GENJUSHEDING,aWEIZUIZHONGDETIJIJIANSHAODU,aZHIYUEXIAOZEFENTILIUDONGXINGYUEHAO;1/bYUEXIAO,JIDADAOSUONENGTIANCHONGZUIXIAOTIJIDEQINGQIAOCISHUYUESHAO,SHUOMINGFENTIDECHONGTIANXINGYUEHAO[4]。

AG奔驰宝马多人版5.ZONGHEKAERZHISHUFAPINGJIALIUDONGXING

MEIGUOYAODIANHEOUZHOUYAODIANPUBIANCAIYONGJIYUCELIANGKELIMOCAFANGFA,JIDUIFENTIDEXIUZHIJIAO、YASUODU、PINGBANJIAO、NINGJIDUHUOJUNQIDUDENGZHIBIAOJINXINGCEDING,JIANGCEDINGJIEGUOYIJUQIDUILIUDONGXINGYINGXIANGDEQIANGRUOCHENGDUZHISHUHUAHOUQIUHELAIPINGGUFENTIDELIUDONGXING。KAERLIUDONGXINGZHISHUFARENWEI,FI≥60DEFENTIWEILIUDONGXINGJIAOHAODEFENTI,BIANYUSHUSONGCAOZUO;60>FI≥40DEFENTIRONGYIFASHENGSHUSONGGUANDAODEDUSAI;FI<40DEFENTIWEILIUDONGXINGBUHAODEFENTI,BUBIANYUSHUSONGCAOZUO,BINGQIEHOULIANGZHEZAISHENGCHANGUOCHENGZHONGDOUXUYAOCAIQUZHULIUHUOHUACUOSHI。


上述表征粉末流动性参数的测量装置很多,但由于标准化程度不高,受人为因素影响较大,同一个粉末用不同的仪器测量,往往会得到不同的数据,影响测量的客观性,进而影响生产工艺、产品质量和效率。丹东百特仪器有限公司所生产的智能综合粉体特性测试仪AG奔驰宝马多人版符合多项国际标准和药典,均能满足上述流动性测量的要求,结果准确,受人为因素影响小。


图像颗粒分析仪哪家好


CANKAOWENXIAN

[1]GAOCHUNSHENG. FENMOZHIJIEYAPIANGONGYI: ZHIYAOGONGYEZHENGTIFAZHANDEZHUTUIJI[J]. GUOJIYAOXUEYANJIUZAZHI, 2009, 36(1):1-5.

AG奔驰宝马多人版[2]CUIFUDE. YAOJIXUE[M]. 6BAN, BEIJING: RENMINWEISHENGCHUBANSHE, 2007:330-333.

AG奔驰宝马多人版[3]WANGCHENGUANG,FANGJIANGUO.YAOWUFENTILIUDONGXINGDECELIANGHEYINGYONG[J].ZHONGGUOXINYAOZAZHI,2013,22(7) :809-813.

AG奔驰宝马多人版[4]CHENSHENGJUN,ZHUJIABIDENG. FENMOZHIJIEYAPIANCHANGYONGFULIAODEFENTIXUEXINGZHIPINGJIA[J].ZHONGGUOYIYAOGONGYEZAZHI, 2013,44(7) :1010-1013.              

 

BENWENZUOZHE:DANDONGBAITEYINGYONGSHIYANSHI GUANQINGYU


相关标签:图像颗粒分析仪价格,图像颗粒分析仪厂家,图像颗粒分析仪哪家好

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